中国药理学通报2011，Vol.27Issue(1)：129-133,5.
热杀死结核分支杆菌H37Ra诱导的SD大鼠佐剂性关节炎模型研究
Research of adjuvant-induced arthritis after mycobacterium tuberculosis H37Ra immunized in SD rats
摘要
Abstract
Aim To analyze the hematology, function of T cell and patho-changes of synovium of AA model induced by Mtb,and estimate the similarity between AA model and RA.Methods AA model was induced with Mtb injection to SD rats.and then the peripheral blood routine.blood theology, peripheral blood lymphocyte( PBL) apoptosis ratio.regulatory T cells ratio, synoviocyte apoptosis ratio and patho-changes of synovium were objectively recorded.Results After Mtb-immunized adjuvant arthritis in SD rats.the haemoglobin decreased; platelet,hematocrit.blood viscosity and plasma viscosity increased; PBL apoptosis ratio decreased obviously; regulatory T cells ratio of CD4+ CD25+ FOXP3 + T cells and CD4+ CD25 + T cells decreased; synoviocyte apoptosis decreased; synovial membrane was hyperplastic, and many inflammatory cells infiltrated, and granulation tissue emerged in it.Conclusions The SD rat AA model induced by Mtb is easy to make and the achievement ratio is high, and its clinical manifestations and histological changes are similar to those of human beings.In addition, this model shows obvious cellular immunological abnormality.To summarize, this method to huild an AA model is worth to use widely inRA study and anti-RA drugs research.关键词
佐剂性关节炎/热杀死结核分支杆菌H37Ra/血液学/细胞凋亡/调节性T细胞/滑膜细胞分类
医药卫生引用本文复制引用
陈佩虹,陈育尧,林晓春,苏健淦,佟丽..热杀死结核分支杆菌H37Ra诱导的SD大鼠佐剂性关节炎模型研究[J].中国药理学通报,2011,27(1):129-133,5.基金项目
美国国立卫生研究院(NIH)补充替代医学研究基金(No FO5AT002013-03) （NIH）
广东省科技厅社会发展计划项目(No 2006B35604001) （No 2006B35604001）
广州市科技局项目(No 2007JI-COO81) （No 2007JI-COO81）
