临床口腔医学杂志2011，Vol.27Issue(2)：70-72,3.DOI:10.3969/j.issn.1003-1634.2011.02.002
慢性牙周炎龈沟液中KGF-1含量检测及其意义
Detection and clinical benefits of keratinocyte growth factor KGF-1 in gingival crevicular fluid in the patients with periodontitis.
赵哲 1武云霞 1孙晓军1
作者信息
- 1. 山西医科大学附属第一医院口腔科,山西,太原,030001
- 折叠
摘要
Abstract
Objective: To detect the concentration of keratinocyte growth factor (KGF)-1 in gingival crevicular fluid (GCF) in the patients with chronic periodontitis before treatment and in different periods after treatment,to research the relationship between KGF-1 in GCF and periodontitis and the effect of KGF-1 in pathogenesis of periodontitis and its progressiveness. Method:The concentration of KGF-1 in GCF were detected by way of enzyme-linked immunosorbent assay following careful sampling of GCF with the standardized filter strips in healthy adults as well as periodontitis patients before treatment and in different stages after treatment. Result:The concentration of KGF-1 in GCF in the inflammatory group was significant higher than the normal group (P ＜0.05),at the fourth week,sixth week and the eighth week after the treatment,the concentration of KGF-1 in GCF was lower than inflammatory group before treatment and significant deference of KGF-1 concentration and statistical significance were found before treatment and in different stages after treatment (P ＜0.05). The concentration of KGF-1 in GCF was significantly associated with the probing depth、attachment loss and sulcus bleeding index. Conclusion:There is a close correlation between the level of KGF-1 in GCF and the degree of periodontal inflammation. The level of KGF-1 in GCF can be regarded as beneficial index that reflect the status of periodontitis.关键词
牙周炎/龈沟液/KGF-1Key words
periodontitis/ gingival crevicular fluid: keratinocyte growth factor-1分类
医药卫生引用本文复制引用
赵哲,武云霞,孙晓军..慢性牙周炎龈沟液中KGF-1含量检测及其意义[J].临床口腔医学杂志,2011,27(2):70-72,3.
