中国组织工程研究与临床康复2011，Vol.15Issue(8)：1402-1404,3.DOI:10.3969/j.issn.1673-8225.2011.08.017
谷维素-壳聚糖缓释微囊的制备
Preparation of oryzanol-chitosan microcapsules
摘要
Abstract
BACKGROUND:Chitosan has a good biocompatibility and biodegradability; it can be used as excellent drug controlled release and targeting vector, mucosal absorbent, absorption enhancers. However, the oryzanol sustained-release formulation as well as related literature has not been reported on the market.OBJECTIVE:To investigate the preparation of oryzanol-chitosan microcapsules.METHODS:Oryzanol-chitosan microcapsules were prepared by using of self-made centrifugal sieve granulator under the guidance of coagulation method, and the drug loading and encapsulation efficiency were investigated.RESULTS AND CONCLUSION:The microcapsules were in uniform size, good finish and shape, drug loading of 47.68％,entrapment efficiency of 76.45％ . The coagulation method is simple, stable and good reproducible. The results show that it is practicable to encapsulate oryzanol by using of natural polymer polysaccharide chitosan. The oryzanol-chitosan microcapsules have further development and application value.关键词
谷维素/壳聚糖/海藻酸钠/载药量/包封率分类
医药卫生引用本文复制引用
顾杰波,范春雷,胡林峰,李浩榕..谷维素-壳聚糖缓释微囊的制备[J].中国组织工程研究与临床康复,2011,15(8):1402-1404,3.基金项目
浙江省科技计划项目(2006C33006). （2006C33006）
