北京中医药大学学报2011，Vol.34Issue(2)：140-144,5.
石氏"醒脑开窍针法"对脑缺血再灌模型大鼠血浆
Influences of Shi's acupuncture therapy of awakening brain and opening orifices on plasma content of AngⅡ, CGRP and ET in rat model of cerebral ischemia-reperfusion
郑宇 1魏惠芳 2张露芬 2任晓暄 2王春生 3张帆 4闫明茹 5周登芳 6郑玲 7孙洁2
作者信息
- 1. 中国核工业北京401医院,北京,102413
- 2. 北京中医药大学针灸推拿学院
- 3. 北京回龙观社区卫生服务中心
- 4. 北京市中医医院
- 5. 中国中医科学院广安门医院
- 6. 北京市肿瘤医院
- 7. 北京医院
- 折叠
摘要
Abstract
Objective To observe the effects and significance of Shi's acupuncture therapy of awakening brain and opening orifices on the plasma content of angiotensin Ⅱ ( AngⅡ ), calcitonia gene related peptide(CGRP) and endothelin(ET) in rat model of cerebral ischemia-reperfusion. Methods The rat model was established by using thread approach, and then treated with Shi's acupuncture therapy of awakening brain and opening orifices and Xiangdan Injection at different intervention times. After successful modeling for 72 hours, the plasma content of AngⅡ, CGRP and ET were detected by applying radioimmunoassay. Results Acupuncture reverted the disordered ratio between CGRP and AngⅡ or ET in rat model of cerebral ischemia-reperfusion in varying degrees. Conclusion The early intervention of acupuncture plays an important role in the development of cerebral ischemia-reperfusion through regulating rennin-angiotensin system, ET and CGRP. Shi's acupuncture therapy of awakening brain and opening orifices can correct the abnormal content of AngⅡ, CGRP and ET based on holistic regulation, which has therapeutic effectiveness and necessity of treatment course.关键词
醒脑开窍针法/脑缺血再灌注/血管紧张素Ⅱ/内皮素/降钙素基因相关肽/大鼠Key words
acupuncture therapy of awakening brain and opening orifices/ cerebral schemia-reperfusion/angiotensin Ⅱ/endothelin/ calcitonia gene related peptide/ rats分类
医药卫生引用本文复制引用
郑宇,魏惠芳,张露芬,任晓暄,王春生,张帆,闫明茹,周登芳,郑玲,孙洁..石氏"醒脑开窍针法"对脑缺血再灌模型大鼠血浆[J].北京中医药大学学报,2011,34(2):140-144,5.
