中国中医药信息杂志2011，Vol.18Issue(2)：50-52,3.DOI:10.3969/j.issn.1005-5304.2011.02.020
敦煌石室大宝胶囊对亚急性衰老大鼠脑功能的保护效应及作用机制研究
Study on the Protective Function and Its Mechanism of Dunhuang Shishi Dabao Capsule on Brain Function of Subacutely Aging Rats
摘要
Abstract
Objective To study the protective function and its mechanism of Dunhuang Shishi Dabao Capsule (DHDB) on brain function of sub-acutely aging rats. Methods Except normal group, the subacutely aging model rats were made by injecting D-gal into abdominal cavity continually and divided into 5 groups randomly: model group, positive control group and high, middle, low dose of DHDB group. After treated with corresponding drugs, cerebral cortex NE, DA, 5-HT, Na+-K+-ATPase, Ca2+-ATPase, Ca2+-Mg2+-ATPase and Ca2+ levels were detected. Results NE, DA, 5-HT, Na+-K+-ATPase, Ca2+-ATPase and Ca2+-Mg2+-ATPase levels in model group were significantly downregulated compared with normal group (P ＜0.05), Ca2+ level was increased significantly (P ＜ 0.05). After treated with DHDB, NE, DA, 5-HT, Na+-K+-ATPase,Ca2+-ATPase and Ca2+-Mg2+-ATPase levels were significantly upregulated (P ＜0.05), Ca2+ level was reduced significantly (P＜0.05). Conclusions DHDB can upregulate monoamine neurotransmitter levels and regulate calcium homeostasis in the brain tissue of aging model rats, and play an important role in improving the aging cerebral function.关键词
单胺类神经递质/钙稳态/亚急性衰老模型/敦煌石室大宝胶囊分类
医药卫生引用本文复制引用
程容,成映霞,段永强,王道坤,朱立鸣,梁玉杰..敦煌石室大宝胶囊对亚急性衰老大鼠脑功能的保护效应及作用机制研究[J].中国中医药信息杂志,2011,18(2):50-52,3.基金项目
甘肃省科技攻关计划(2GS064-A43-020-22) （2GS064-A43-020-22）
兰州市科技局计划项目 （）
