中国药房2011，Vol.22Issue(10)：913-916,4.
国内盐酸法舒地尔治疗蛛网膜下腔出血后脑血管痉挛的有效性和安全性系统评价
Effectiveness and Safety of Fasudil Hydrochloride in the Treatment of Cerebral Vasospasm after Subarachnoid Hemorrhage in China: a Systematic Review
任林 1苏娜 2唐尧2
作者信息
- 1. 四川大学华西药学院,成都市,610041
- 2. 四川大学华西医院,成都市,610041
- 折叠
摘要
Abstract
OBJECTIVE: To evaluate the effectiveness and safety of fasudil hydrochloride in the treatment of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH). METHODS: Random controlled trails (RCT) on fasudil hydrochloride treatment for CVS after SAH were gathered from CBM, CNKI, Wanfang database, VIP. Other relative researches were searched manually. Methodological quality of included researches was evaluated, and meta-analysis was carried out by RevManS.0 software. RESULTS: A total of 19 RCT were collected. Results of Meta-analysis showed that for the total effective rate and the incidence of cerebral vasospasm, there was no significant differences between fasudil 30 mg, q 8 h and nimodipine 24 mg·d-1. RR and 95％CI were equal to 1.06 (0.98, 1.16) and 1.17 (0.53, 2.59). The differences of the total effective rate between trail group and nimodipine 10 mg·d-1 had statistical significance, and the RR and 95％CI were 1.30 (1.11, 1.52). CONCLUSION: According to the current evidence in China, the treatment of fasudil for CVS after SAH can increase the total effective rate and reduce the incidence of cerebral vasospasm. The difference of effectiveness between fasudil and nimodipine is affected by dose and route of administration.关键词
法舒地尔/蛛网膜下腔出血/随机对照试验/Meta分析分类
医药卫生引用本文复制引用
任林,苏娜,唐尧..国内盐酸法舒地尔治疗蛛网膜下腔出血后脑血管痉挛的有效性和安全性系统评价[J].中国药房,2011,22(10):913-916,4.
