癌症2011，Vol.30Issue(2)：96-105,10.
Ancient migration routes of Austronesian-speaking populations in oceanic Southeast Asia and Melanesia might mimic the spread of nasopharyngeal carcinoma
Ancient migration routes of Austronesian-speaking populations in oceanic Southeast Asiaeal carcinoma
Jean Trejaut 1Chien-Liang Lee 1Ju-Chen Yen 1Jun-Hun Loo 1Marie Lin1
作者信息
- 1. Mackay Memorial Hospital, #45 Min-Sheng Road, Tamsui 25115, Taiwan
- 折叠
摘要
Abstract
Mitochondrial DNA (mtDNA) and non-recombining Y chromosome (NRY) are inherited uni-parentally from mother to daughter or from father to son respectively. Their polymorphism has initially been studied throughout populations of the world to demonstrate the "Out of Africa" hypothesis. Here, to correlate the distribution of nasopharyngeal carcinoma (NPC) in different populations of insular Asia, we analyze the mtDNA information (lineages) obtained from genotyping of the hyper variable region (HVS Ⅰ & Ⅱ) among 1400 individuals from island Southeast Asia (ISEA), Taiwan and Fujian and supplemented with the analysis of relevant coding region polymorphisms. Uneages that best represented a clade (a branch of the genetic tree) in the phylogeny were further analyzed using complete genomic mtDNA sequencing. Finally, these complete mtDNA sequences were used to construct a most parsimonious tree which now constitutes the most up-to-date mtDNA dataset available on ISEA and Taiwan. This analysis has exposed new insights of the evolutionary history of insular Asia and has strong implications in assessing possible correlations with linguistic, archaeology, demography and the NPC distribution in populations within these regions. To obtain a more objective and balanced genetic point of view, slowly evolving biallelic Y single nucleotide polymorphism (Y-SNP) was also analyzed. As in the first step above, the technique was first applied to determine affinities (macro analysis) between populations of insular Asia. Secondly, sixteen Y short tandem repeats (Y-STR) were used as they allow deeper insight (micro analysis) into the relationship between individuals of a same region. Together, mtDNA and NRY allowed a better definition of the relational, demographic, cultural and genetic components that constitute the make up of the present day peoples of ISEA. Outstanding findings were obtained on the routes of migration that occurred along with the spread of NPC during the settlement of insular Asia. The results of this analysis will be discussed using a conceptual approach.关键词
Mitochondrial DNA/ polynesian motif/ Out of Taiwan/ Austronesian speakersKey words
Mitochondrial DNA/ polynesian motif/ Out of Taiwan/ Austronesian speakers引用本文复制引用
Jean Trejaut,Chien-Liang Lee,Ju-Chen Yen,Jun-Hun Loo,Marie Lin..Ancient migration routes of Austronesian-speaking populations in oceanic Southeast Asia and Melanesia might mimic the spread of nasopharyngeal carcinoma[J].癌症,2011,30(2):96-105,10.
