江苏大学学报（医学版）2011，Vol.21Issue(1)：1-4,4.
外源性一氧化碳释放分子对脓毒症小鼠血小板膜糖蛋白CD41、CD61和CD62p表达的影响
Effect of extrinsic carbon monoxide-releasing molecules Ⅱ on expressions of CD41/CD61 and CD62p on the platelet membrane surface in mice with CLP
摘要
Abstract
Objective: To investigate the effects of extrinsic carbon monoxide -releasing molecules Ⅱ ( CORM-2) on the expressions of CD41/CD61 and CD62p on the platelet membrane surface in mice with cecal ligation and puncture ( CLP) . Methods: Sixty male C57BL/6 mice were ranclomly divided into sham ,CLP ,CLP ＋ CORM－2 , O2 ＋ CLP ＋ CORM－2 groups. One group were randomly divided into 6 h, 12 h and 24 h. The mean immunofluorescence intensity of CD 41 , CD61or positive percentage of CD62p was measured by the flow cytometry ( FCM) . Results : The mean fluorescence intensity of CD61 and positive percentage of CD62p on platelet membrane respectively in O2 ＋ CORM－2 ＋ CLP group were significantly decreased while comparecl with CLP group and were approximated with control Sham group . Conclusion: The extrinsic carbon monoxide-releasing molecules Ⅱ may induce down regulation of platelet membrane glycoprotein CD 61 and CD62p expression in CLP mice , with inhibiting that platelet activation.关键词
外源性一氧化碳释放分子/盲肠结扎和穿孔小鼠/血小板膜糖蛋白分类
医药卫生引用本文复制引用
杨国涛,孙炳伟,邹向前,王敏..外源性一氧化碳释放分子对脓毒症小鼠血小板膜糖蛋白CD41、CD61和CD62p表达的影响[J].江苏大学学报（医学版）,2011,21(1):1-4,4.基金项目
国家自然科学基金资助项目(30772256,81071546) （30772256,81071546）
江苏省自然科学基金资助项目(BK2008237) （BK2008237）
江苏省政府留学基金资助项目(2008-K002) （2008-K002）
