中国比较医学杂志2011，Vol.21Issue(1)：16-22,封2,8.DOI:10.3969/j.issn.1671.7856.2011.01.004
两种自发性2型糖尿病小鼠生物学特性比较
Two Spontaneous Type 2 Diabetic Mice and Their Difference of Phenotype
摘要
Abstract
Objective To investigate biological parameters and morphology in spontaneous type 2 diabetic KK-Ay/ Ta and C57BL/KsJ-db/db mice.Methods In experiment the body weight, glucose and serum insulin were measured every two weeks.At the end of experiment, the mice were sacrificed for organ, fat weight and morphological study.Results ① The weight of KK mice were higher than that of db/db mice, and the male's were higher than the female's in the same strain(P ＜0.05).② The glucose of male mice were higher than the female, the abnormal glucose levels of db/db mice were detected earlier and higher than those of KK mice( P ＜ 0.05 ).But duration of KK mice' abnormal glucose was longer than db/db mice.③ The serum insulin of KK mice were higher over db/db mice significantly( P ＜ 0.05 ) , and they did not have obvious difference in the same strain(P ＞0.05).④ The fat to body weight ratios and atrophy of some viscera in male KK mice were more serious than the female, but there was no obvious difference in db/db mice.Atrophy of spleen and pancreas of db/db mice became more serious than that of KK, however, so did in liver of KK mice.The fat to body weight ratios of db/db mice was elevated than those of KK mice ( P ＜ 0.05 ).⑤ The spleen, liver and pancreas of diabetic mice model had serious pathological deterioration.Conclusions The KK and db/db mice could be used as appropriate disease models of type 2 diabetes mellitus with hyperglycemia, hyperinsulinemia, obesity.关键词
小鼠/2型糖尿病/血糖/血清胰岛素/组织损伤分类
医药卫生引用本文复制引用
李娜,张周..两种自发性2型糖尿病小鼠生物学特性比较[J].中国比较医学杂志,2011,21(1):16-22,封2,8.基金项目
重大新药创制国家科技重大专项(2009ZX09301-001) （2009ZX09301-001）
中国科学院战略生物资源技术支撑体系专项(CZBZX-1). （CZBZX-1）
