解放军医学杂志2011，Vol.36Issue(1)：64-67,4.
高血压患者左心室结构与运动耐量的相关性研究
The correlation between left ventricular structure and exercise tolerance of patients with essential hypertension
摘要
Abstract
Objective To investigate the correlation between the structure of the left ventricle and exercise tolerance of patient with essential hypertension Methods The clinical data of 339 hypertensive patients (226 males and 113 females) were consecutively collected from Feb. 2008 to Feb. 2010 in cardiovascular clinic of Zhejiang Hospital All the patients underwent Doppler echocardiography in order to appraise the left ventricular structure, and walking tolerance was assessed by 6-minute walk distance test. During each test, peak oxygen consumption (VO2) was measured using a portable metabolic system. The patients were divided into two groups according to left ventricular mass index (LVMI), hypertension with left ventricular hypertrophy (LVH) (n= 145) and hypertension without LVH (n= 194). Unadjusted correlation analysis and stepwise multiple regression analysis were used to investigate the correlation between the left ventricular structure, e.g. left ventricular end diastolic dimension (LVEDD), left ventricular end systolic dimension (LVESD),interventricular septal thickness (IVST) and posterior wall thickness (PWT), LVMI, and 6.minute walk distance and peak VO2. Reselts Unadjusted correlation analysis showed that LVEDD (r=-0. 157, P=0. 004), LVESD (r=-0. 139, P=0. 01), IVST (r=-0. 193,P＜0.001) and LVMI (r=-0. 229, P＜0.001) were negatively correlated with the 6-minute walk distance. PWT (r=-0.12a, P= 0.02), IVST (r=-0. 134, P=0. 02), and LVMI (r=-0. 182, P＜0. 001) were negatively correlated to peak VO2. Stepwise multiple regression analysis showed that the LVMI was an independent determinant for both 6.minute walk distance (R2 =0. 04, P=0. 002) and peak VO2 (R2 =0. 026, P＜0. 001). Both 6-minute walk distance and peak VO2 decressed in hypertensive patients with LVH [(435.1± 7. 64m and 15. 9±0. 44ml/(min · kg)] compared with that of hypertensive patients without LVH [477. 4±6. 64m and 18. 0±0. 38ml/(min · kg)] (P＜0. 001). Conclusions Left ventricular structure is significantly associated with exercise tolerance in hypertensive patients.LVM] is an independent determinant for both 6.minute walk distance and peak VO2.关键词
高血压/左室重量指数/运动耐量Key words
hypertensions left ventricular mass index/ exercise tolerance分类
医药卫生引用本文复制引用
李莉,蔡国龙,徐强宏,严静,龚仕金,宁钢民,余海燕,杨桂秋,任寅姿,戴海文,陈进..高血压患者左心室结构与运动耐量的相关性研究[J].解放军医学杂志,2011,36(1):64-67,4.基金项目
浙江省科技厅重大项目(2006C13018) （2006C13018）
浙江省人事厅留学回国人员科技活动择优资助项目(2003-001) （2003-001）
浙江省老年医学重点学科群招标项目(2009ZB005) （2009ZB005）
