中国人兽共患病学报2011，Vol.27Issue(2)：127-131,5.
福建省甲型H1N1流感血清流行病学调查
Serologic survey on 2009 pandemic influenza A (H1N1) in Fujian Province
摘要
Abstract
This study was aimed at investigating the serologic responses to 2009 pandemic influenza A (H1N1) virus in Fujian Province before and after the H1 N1 pandemic. Before the occurrence of the H1N1 pandemic, 800 serum specimen were obtained in 2008, whereas 1250 specimen were taken from different districts from January to April, after the pandemic in 2010.Antibody titres were measured by using haemagglutination inhibition (HI) assay. The results showed that the positive rates of HI≥10 and HI≥40 after the pandemic were increased to 52.72％ and 36.24 from 6.5％ and 0.63％ respectively before the pandemic (P＜0.01), and geometric mean titer (GMT) was increased to 18.26 from 5.39 (P＜0.01). The levels of HI antibody after the pandemic was significantly higher than those before the pandemic in each age group (P＜0.01). The positive rates of HI≥10, HI≥40 and GMT in the subjects of 6-17 years old were 74.02％, 57.22％ and 38.15 respectively, which were the highest among various age groups. There were no significant difference in the levels of HI antibody between males and females (P＞0.05). The levels of HI antibody in the subjects from Fuzhou were the highest among 9 prefectures. The positive of HI≥10, HI≥46 and GMT in the subjects received H1N1 vaccination were 83.84％, 64.62％ and 46.62 respectively, which were significantly higher than those in the subjects without vaccination. Our data revealed that the levels of HI antibody had been significantly increased and the development of immunological barrier to 2009 pandemic influenza A (H1N1) virus had been formed, to some extent after the pandemic in Fujian Province. However, mass vaccination campaigns targeting the key age groups should be strengthened to prevent the rebound of pandemic.关键词
甲型H1N1流感/血清流行病学/HI抗体分类
医药卫生引用本文复制引用
郑奎城,沈晓娜,杨式芹,林元波,周朝晖,谢剑锋,陈炜,翁育伟,严延生..福建省甲型H1N1流感血清流行病学调查[J].中国人兽共患病学报,2011,27(2):127-131,5.基金项目
国家传染病防治科技重大专项"突发传染病病原体快速检测与现场机动采样技术平台研究"(2009ZX10004-106)联合资助 （2009ZX10004-106）
