同济大学学报（医学版）2011，Vol.32Issue(1)：77-81,5.DOI:10.3969/j.issn1008-0392.2011.01.077
首次脑梗死后抑郁障碍的临床研究
Clinical study of depressive disorder after first-ever cerebral infarction
何育生 1封亮 1赵丽娟 1陈玉辉 1王星1
作者信息
- 1. 同济大学附属同济医院神经内科,上海,200065
- 折叠
摘要
Abstract
Objective To study the risk factors and pathogenesis for depression, a common complication among stroke patients, after first-ever cerebral infarction.Methods Two hundred and two patients after first-ever ischemic stroke were investigated prospectively to evaluate the prevalence of depressive disorder, the relationship between depression and stroke subtypes and severity of neurological function deficits.Risk factors of depressive disorder were studied by Logistic regression.Results Prevalence of depressive disorder after first-ever cerebral infarction was 18.8％.Old patients were likely to the develop depression ( P= 0.024 ).Patients with total anterior cerebral infarction (TACI) showed a higher occurrence and severity score of depressive disorder than those with other oxfordshire community stroke project (OCSP) subtypes.Some risk factors, including female ( P=0.048 ), many coexisting risk factors of stroke ( P = 0.018 ), dysphasia ( P = 0.005 ) and severity of neurological function deficits ( P= 0.000 ) were considered as independent predictors of depression occurrence by Logistic regression.It showed no association between depression and territorial infarction in dominant hemisphere or in two different cerebral artery systems.Conclusions Depressive disorder associated with severity of neurological function deficits is found to be an important complication in patients with first-ever cerebral infarction.Biopsychosocial medical model may play an important role in the development of poststroke depression.关键词
脑梗死/抑郁障碍/危险因素/发病机制分类
医药卫生引用本文复制引用
何育生,封亮,赵丽娟,陈玉辉,王星..首次脑梗死后抑郁障碍的临床研究[J].同济大学学报（医学版）,2011,32(1):77-81,5.
