西安交通大学学报（医学版）2011，Vol.32Issue(1)：69-71,101,4.
自发性高血压大鼠纤维结合蛋白的表达及氯沙坦的干预作用
Effects of lorsartan on fibronectin's expression in spontaneously hypertensive rats
摘要
Abstract
Objective To observe the effects of lorsartan on serum and urinary fibronectin (Fn) levels and the renal expression of Fn in spontaneously hypertensive rats (SHRs).Methods Sixteen male 14 week-old SHRs were randomly divided into hypertensive group (SHR group) and losartan group (T-SHR group) administered by gastric lavage of losartan 30 mg/(kg · d), each group consisting of eight SHRs; eight male 14 week-old Wistar Kyoto rats served as negative control group (WKY group).After 16 weeks, the weight and systolic pressure of rats in each group were observed.The serum and urinary Fn levels were measured by enzyme-linked immunoadsorbent assay (ELISA) and the renal expression of FN was determined by immunohistochemical analysis in different groups.Results ① The systolic pressure and urinary Fn level in SHR group were significantly higher than those in WKY group (P＜0.05).The level of serum Fn was significantly lower in SHR group than in WKY group (P＜0.05).The expression of Fn in renal tubulointerstitium, mesangial cells and Bownman's capsule increased greatly in SHR group compared with those in WKY group (P＜0.05).② The systolic pressure and urinary Fn level in T-SHR group were significantly lower than those in SHR group (P＜0.05).The level of serum Fn in T-SHR group was significantly higher than that in SHR group (P＜0.05).The renal expression of Fn was significantly lower in T-SHR group than in SHR group (P＜0.05).Conclusion The level of urinary Fn increased, that of serum Fn decreased and the renal expression of Fn increased.Lorsartan has protective effects on early hypertension-induced renal lesion by partly inhibiting the renal expression of Fn.关键词
氯沙坦/自发性高血压/大鼠/纤维结合蛋白分类
医药卫生引用本文复制引用
敖翔,李强翔,周巧玲..自发性高血压大鼠纤维结合蛋白的表达及氯沙坦的干预作用[J].西安交通大学学报（医学版）,2011,32(1):69-71,101,4.基金项目
①湖南省卫生厅科技计划项目(No.B2006-215) （No.B2006-215）
②娄底市科技局科技项目(No.娄市科学[2007]15号) （No.娄市科学[2007]15号）
③湖南省博士后研究人员日常经费资助(2009年44号) （2009年44号）
④中南大学第十四批博士后科学基金资助项目 （）
