实用肝脏病杂志2011，Vol.14Issue(2)：114-115,2.DOI:10.3969/j.issn.1672-5069.2011.02.011
拉米夫定联合阿德福韦酯治疗耐药株感染慢性乙型肝炎37例临床观察
Observation upon curative effect of lamivudine and adefovir combination therapy on patients with chronic hepatitis B
成娟 1蔡文辉 1施翠芬1
作者信息
- 1. 224003,江苏省盐城市第二人民医院感染病科
- 折叠
摘要
Abstract
Objective To observe the effecr of lamivudine and adefovir combination therapy on patients with chronic hepatitis B. Methods 11 patients tolerated lamivudine switched to adefovir,6 tolerated to adefovir switched to lamivudine,and 28 tolerated lamivudine and 9 tolerated adefovir switched to lamivndine and adefovir combination therapy. Results At the end of 48 weeks therapy,the serum HBV DNA negative rate(76％)and ALT normalization rate(92％)in combination group were much higher than in adefovir(45％,73％)or lamivudine(50％,83％)groups. Conclusion The combination of lamivudine and adefovir therapy is an alternative option in hepatitis B patients tolerated to adefovir or lamivtudine.关键词
慢性乙型肝炎/拉米夫定/阿德福韦酯/病毒耐药引用本文复制引用
成娟,蔡文辉,施翠芬..拉米夫定联合阿德福韦酯治疗耐药株感染慢性乙型肝炎37例临床观察[J].实用肝脏病杂志,2011,14(2):114-115,2.
