安徽农业科学2011，Vol.39Issue(3)：1357-1358,2.
和厚朴酚的合成研究
Study on Synthesis of Honokiol
刘之华 1童志平1
作者信息
- 1. 西南交通大学生命科学与工程学院,四川成都610031
- 折叠
摘要
Abstract
This article provides one way for the synthesis of honokiol: taking 4-Bromo Anisole and 4-allylanisole as raw materials, 4-Bromo Anisole had chemical reaction under 40 ℃ in THF and isopropyl magnesium chloride. Then added with allyl-bromide, 4-bromo-2-allyl anisole was obtained. Under certain conditions, 4-allylanisole generated 2-bromo-4-allyl anisole. Formulating 4-bromo-2-allyl anisole to corresponding Grignard reagent so as to cross-coupling with 2-bromo-4-allyl anisole after been catalyzed by NiC12 ( PPh3 ) 2, Honokiol methyl ether was obtained thusly. After hydrolyzing Honokiol methyl ether, honokiol was generated.关键词
和厚朴酚/合成/格氏试剂Key words
Honokiol/ Synthesis/ Grignard reagent分类
农业科技引用本文复制引用
刘之华,童志平..和厚朴酚的合成研究[J].安徽农业科学,2011,39(3):1357-1358,2.
