局解手术学杂志2011，Vol.20Issue(1)：20-21,2.
四氧嘧啶诱导1型糖尿病动物模型的建立
Establishment of type 1 diabetes mellitus animal model induced by alloxan
摘要
Abstract
Objective To induce type 1 diabetes mellitus animal model with middle dose of alloxan.Methods Totally 150 SD rats were selected and divided into 5 groups ( n = 30), group 1, group 2, group 3, group 4 and control group.group 1 to 4 were given 140, 150,160, 170mg/kg alloxan by intraperitoneal injection respectively while control group was given equal mount of normal saline after fasting for 12 hours.Their blood glucoses were measured 24 hours later and once every two weeks until the sixth month.Results After injection for 24 hours, model forming rates in group 1 to4 were 23.3％, 30％, 30％, 33.3％ respectively; Six months later, their model forming rates were 13.3％, 26.7％, 30％, 26.7％ respectively.Blood glucose concentration in control group was always normal.Conclusion Type 1 diaberes mellitus animal model with low model forming rate as well as stable and long-term etfect can be established by intraperitoneal injection of 150 ～ 160 mg/kg alloxan.关键词
四氧嘧啶/糖尿病/动物模型/大鼠分类
医药卫生引用本文复制引用
代小思,康健,万芮菡,荣阳玲,王婷..四氧嘧啶诱导1型糖尿病动物模型的建立[J].局解手术学杂志,2011,20(1):20-21,2.基金项目
四川省科技厅重点攻关课题(05SG1868) （05SG1868）
