广东药学院学报2011，Vol.27Issue(1)：10-13,4.DOI:10.3969/j.issn.1006-8783.2011.01.003
枸橼酸铋雷尼替丁胃漂浮缓释片的研究
Study on ranitidine bismuth citrate intra-gastric floating sustained-release tablets
任新荣 1王志国 2叶冠豪 2冯汉林1
作者信息
- 1. 安徽中医学院,药学院,安徽,合肥,230031
- 2. 深圳海王生物工程股份有限公司,广东,深圳,518057
- 折叠
摘要
Abstract
Objective To prepare ranitidine bismuth citrate intra-gastric floating sustained-release tablets with hydroxypropylmethylcellulose( HPMC ) as the matrix material. Methods The effects of the specification of HPMC、the amount of stearic acid and Polyvinyl polypyrrolidone( PVPP) 、solidity on the floation and release behavior were investigated by single-factor tests to optimize the formulation; The stability of tablets were examined. Results HPMC (20％ ) ,stearic acid ( 35％ ) and PVPP ( 2％ ) were selected as excipients of the tablets. The beginning floating time of ranitidine bismuth citrate intra-gastric floating sustained-release tablets was less than 10 min,lasting for more than 20 h. The tablets had good behavior of floating and release characteristics. Conclusion The preparation process is simple, which is worth further development and application in the clinic.关键词
枸橼酸铋雷尼替丁/胃漂浮缓释片/羟丙甲基纤维素分类
医药卫生引用本文复制引用
任新荣,王志国,叶冠豪,冯汉林..枸橼酸铋雷尼替丁胃漂浮缓释片的研究[J].广东药学院学报,2011,27(1):10-13,4.
