老年心脏病学杂志（英文版）2008，Vol.5Issue(3)：179-181,3.
Ettects of simvastatin on ion channel currents in ventricular myocytes from rabbit with acute myocardial infarction
Ettects of simvastatin on ion channel currents in ventricular myocytes from rabbit with acute myocardial infarction
Chao Ding 1Xianghua Fu 2Li Yang 1Huixiao Chen 1Junxia Li 1Yuying Zhao 1Jie Li 1Jie Wang1
作者信息
- 1. Department of Cardiology,Bethune International Peace Hospital of Chinese PLA,Shijiazhuang Hebei 050082 China
- 2. Department of Cardiology,The Second Hospital,Hebei Medical University,Shijiazhuang Hebei 050000.China
- 折叠
摘要
Abstract
Objective To investigate the effects of simvastatin on membrane ionic currents in left ventricular myocytes after acutemyocardial infarction(AML.so as to explore the ionic mechanism of statin treatment for antiarrhythmia.Methods Fourty-five NewZeland rabbits were randomly divided into three groups:AMI group,simvastatin intervention group(statin group)and sham-operatedcontrol group (CON).Rabbits were infarcted by ligation of the left anterior descending coronary artery after administration of oralisolated enzymatically from the epicardial zone of the infractcd region.Whole cell patch clamp technique was used to record mmbranewas significantly decreased in AMI group(-23.26+5.1 8)compared with CON(-42.78±5.48,P＜0.05),while it was significantlyincreased in Stating roup(-39.23±5.45)compared with AMI group(P＜0.01);The peak Ica-L current density(at 0 mV) was significantlydecreased in AMI group(-3.23±0.91)compared with CON(-4.56±1.01,P＜0.05),while it was significantly increased in Statin group(-4.18±0.95)compared with AMI group(P＜0.05);The Ito current density(at+60 mV)was significantly decreased in AMI group(10.41±1.93)compared with CON(17.41±3.13,P＜0.01),while it was significantly increased in Statin group(16.21±2.42)compared withattenuate this change without lowering the serum cholesterol level,suggesting that simvastatin reverse this electrical remodeling thuscontributing to the ionic mechanism of statin treatment for antiarrhythmia.关键词
simvastatin/myocardial infarction/ionie channels/patch-clamp/rabbitKey words
simvastatin/myocardial infarction/ionie channels/patch-clamp/rabbit引用本文复制引用
Chao Ding,Xianghua Fu,Li Yang,Huixiao Chen,Junxia Li,Yuying Zhao,Jie Li,Jie Wang..Ettects of simvastatin on ion channel currents in ventricular myocytes from rabbit with acute myocardial infarction[J].老年心脏病学杂志（英文版）,2008,5(3):179-181,3.
