南方医科大学学报2011，Vol.31Issue(2)：333-337,5.
三维、二维定量冠脉X射线造影与目测对靶病变血管的评估对比研究
A comparative study of target vessel assessments by three- and two-dimensional quantitative coronary X-ray angiography and visual estimation
摘要
Abstract
Objective To investigate the expression levels of miR-146a and miR-16 in the peripheral blood mononuclear cells (PBMCs) of patients with rheumatoid arthritis (RA) and their correlation to the disease activity. Methods The expression levels of miR-146a and miR-16 in the in PBMCs were measured using real-time RT-PCR in 40 RA patients and 16 healthy individuals. The correlations of miR-146a and miR-16 expressions to the disease activity of RA were analyzed. Results The expression levels of miR-146a and miR-16 in the PBMCs of RA patients increased significantly compared to those in the healthy individuals (P<0.05). Their expression levels was significantly higher in active RA patients than in patients with disease remission (P<0.05) and healthy individuals (P<0.01). The expression levels of miR-146a and miR-16 were positively correlated to ESR, CRP and the disease activity scores in 28 joints (DAS28) (P<0.01), but not to RF (P＞0.05). Conclusion The elevated expression levels of miR-146a and miR-16 are correlated to RA disease activity, suggesting their value in assessment of the clinical disease activity of RA.关键词
三维重建/二维重建/定量冠状动脉造影/目测法/X射线/靶病变血管Key words
arthritis, rheumatoid/ microRNA-146a/ microRNA-16分类
医药卫生引用本文复制引用
郝培远,陈爱华,宋旭东,魏向龙,周珊珊,何非,涂圣贤..三维、二维定量冠脉X射线造影与目测对靶病变血管的评估对比研究[J].南方医科大学学报,2011,31(2):333-337,5.基金项目
广东省医学科研基金(2008B030303019) （2008B030303019）
