法医学杂志2011，Vol.27Issue(1)：36-38,3.DOI:10.3969/j.issn.1004-5619.2011.01.010
21个非CODIS STR基因座的遗传多态性
Genetic Polymorphisms of 21 Non-CODIS STR Loci
摘要
Abstract
Objective To investigate genetic polymorphisms of 21 non-CODIS STR loci in Han population from the east of China and to explore their forensic application value. Methods Twenty-one non-CODIS STR loci, were amplified with AGCU 21+1 STR kit and DNA samples were obtained from 225 unrelated individuals of the Hah population from the east of China. The PCR products were analyzed with 3130 Genetic Analyzer and genotyped with GeneMapper ID v3.2 software. The genetic data were statistically analyzed with PowerStats vl2.xls and Cervus 2.0 software. Results The distributions of 21 non-CODIS STR loci satisfied the Hardy-Weinberg equilibration. The heterozygosity (H) distributions were 0.596-0.804, the diserimination power (DP) were 0.764-0.948, the probability of exclusion of duo-testing (PEduo) were 0.1760.492, the probability of exclusion of trios-testing (PEso) were 0.334-0.663, and the polymorphic information content (PIC) were 0.522-0.807. The cumulative probability of exclusion (CPE) of duo-testing was 0.999 707, the CPE of trios-testing was 0.999 9994, and the cumulated discrimination power (CDP) was 0.99999999999999999994. Conclusion Twenty-one non-CODIS STR loci are highly polymorphie. They can be effectively used in personal identification and paternity testing in trios cases. They can also be used as supplement in the difficult cases of diad paternity testing.关键词
法医遗传学/多态现象,遗传/STR/亲子鉴定Key words
forensic genetics/ polymorphism, genetic/ short tandem repeats/ paternity testing分类
社会科学引用本文复制引用
邵伟波,张素华,李莉..21个非CODIS STR基因座的遗传多态性[J].法医学杂志,2011,27(1):36-38,3.基金项目
上海市科技攻关课题项目(08251203200) （08251203200）
上海市自然科学基金项目(08ZR1419800) （08ZR1419800）
