同济大学学报（医学版）2011，Vol.32Issue(1)：73-76,81,5.DOI:10.3969/j.issn1008-0392.2011.01.073
还原型谷胱甘肽对急性胰腺炎肝损害的保护机制
Study on protective mechanism of reduced glutathione on patients with acute pancreatitis-associated liver injury
申振宇 1蒋晓峰 2孙斌 1周莹群 1陶春华 1施嫣红1
作者信息
- 1. 同济大学附属第十人民医院肝胆胰内科,上海,200072
- 2. 同济大学附属同济医院肾内科,上海,200065
- 折叠
摘要
Abstract
Objective To study the protective mechanism of reduced glutathione on patients with acute pancreatitis-associated liver injury. Methods Eighty-four patients with liver injury and acute pancreatitis were randomly divided into two groups: routine treatment group (n= 42) and GSH treatment group (n= 42).Liver function tests, TNF-α, IL-6, IL-10, malondialdehyde (MDA), glutathione peroxidese (GSH-Px) and superoxide dismutase(SOD)were assessed on admission and on the 8th day. Results Compared with the routine treatment, GSH expressed better efficiency in the treatment of patients with acute pancreatitisassociated liver injury (P ＜ 0.05). The serum levels of TNF-α [ (2. 34 ± 0. 15)/ng · ml-1 ] and IL-6 [ (144. 52 ± 10.75) pg · ml - 1 ] after GSH treatment were significantly lower than those in routine treatment group [ (4.30 ± 0.26 )/ng · ml-1; (244.82 ± 15.16)/pg · ml-1, (P = 0. 001 ) ] respectively. While IL-10 (71.57 ±3.07)pg · ml-1 in serum in GSH treatment group was significantly higher than that in routine treatment group [ (65.98 ±3.17)pg · ml-1, (P =0.002 4), the concentrations of TNF-α and IL-6 after GSH treatment were significantly lower than those in routine treatment group [ (4.41 ±0.25)ng · ml -1; (246.62 ±14.78) pg · ml-1, (P= 0. 001)] respectively. The serum level of IL-10 after GSH treatment was significantly higher than that in routine treatment group (67.22 ± 3.25 ) pg · ml - 1, (P = 0. 003 6). The serum MDA(40.08 ± 1.92) μ mol· L- 1 and SOD [ ( 19.75 ± 1.23 ) KU · L- 1 ] levels after GSH treatment were significantly lower than those in routine treatment group (44.07 ± 1.98 ) μ mol· L- 1; (24.52 ±1.21 ) KU · L -1, (P =0. 003 ) 和 (P = 0. 001 ) respectively. However, the serum level of GSH-Px (48.13 ±1.85)μg · L-1 in GSH treatment groupwas significantly higher than that in routine treatment group[ (41.19 ±1.80)μg · L-1 ;P =0.001 ) ]. The concentrations of MDA and SOD after GSH treatment were significantly lower than those in routine treatment group[ (42.37 ± 1.94)μ mol· L-1, (24.14 ± 1.31 ) KU · L-1; (P =0.003 ,P =0.001) ] respectively. Compared with control group[ (40.48 ±1.48) μg · L-1 ], the serum level of GSH-Pxwas significantly higher in GSH treatment group(P =0.001). Conclusion Reduced glutathione has beneficial effects on the treatment of liver injury with acute pancreatitis. The modulating effects of the inflammatory media and oxygen free radical may be involved in this mechanism.关键词
还原型谷胱甘肽/急性胰腺炎/肝损害分类
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申振宇,蒋晓峰,孙斌,周莹群,陶春华,施嫣红..还原型谷胱甘肽对急性胰腺炎肝损害的保护机制[J].同济大学学报（医学版）,2011,32(1):73-76,81,5.
