武汉工程大学学报2011，Vol.33Issue(4)：26-29,4.DOI:10.3969/j.issn.1674-2869.2011.04.007
三氯蔗糖-6-乙酯的制备工艺
Study on chlorination of sucrose-6-acetate
游华彬 1潘志权 1周红1
作者信息
- 1. 武汉工程大学,绿色化工过程省部共建教育部重点实验室,湖北武汉430074
- 折叠
摘要
Abstract
Sucrose-6-acetate was synthesized based on chlorination of vilsmeier reagent by thionyl chloride, which was prepared from sucrose via selective esterification, and the structure was confirmed by IR, 1H NMR;The studies on the process of syntheses show that vilsmeier reagent prepared prior is necessary to increase the yield of chlorination; the most excellent condition for dichloro-substituted reaction is at 98-100℃ for 6h. Chloride reaction solution was extracted with dichloromethane and then crystallized with ethyl acetate-water in 41％ yield. The optimized process of chlorination was simple and more easy to control and suitable for industrial production.关键词
三氯蔗糖-6-乙酯/Vilsmeier试剂/工艺优化Key words
sucralose-6-acetate/ vilsmeier reagent/ process optimization分类
轻工纺织引用本文复制引用
游华彬,潘志权,周红..三氯蔗糖-6-乙酯的制备工艺[J].武汉工程大学学报,2011,33(4):26-29,4.
