中国美容医学2011，Vol.20Issue(5)：787-790,4.
异种肌腱基质材料生物相容性的体外评价实验
Experimental studies on biocompatibility of xenogenic tendon matrix materials in vitro
陈元良 1姜平 1夏学颖 1陈伟 1张伟2
作者信息
- 1. 广州南方医科大学南方医院整形外科,广东,广州,510515
- 2. 广东冠昊生物科技股份有限公司,广东,广州,510663
- 折叠
摘要
Abstract
Objective To evaluate the biocompatibility of novel manufactured xenogenic tendon matrix materials and to provide basis for further experimental study and clinical application.Methods According to the standard for the biological evaluation of the medical devices,the acute toxicity test, sensitization test, skin stimulating test, cellular toxicity test,and genotoxicity test were carried out to evaluate the biocompatibility of the prepared implants.Results No animal died and no toxicity symptom or adverse effects were shown within 72 hours.No obvious sensitivity were observed.Skin stimulating reactions were not found in the experimental groups and negative control group by intradermal stimulation test.The toxicity of materials leaching liquor was graded from 0 to 1,which means the material has no cytotoxicity.Ames test,chromosome aberration test,and micronucleus test of bone marrow cells in mice were negative and lacked toxicity.Conclusion The new xenogenic tendon matrix material has good biocompatibility,and it may be served as a promising implant material.关键词
异种材料/生物相容性Key words
xenogeneic material/biocompatibility分类
医药卫生引用本文复制引用
陈元良,姜平,夏学颖,陈伟,张伟..异种肌腱基质材料生物相容性的体外评价实验[J].中国美容医学,2011,20(5):787-790,4.
