中国临床药学杂志2011，Vol.20Issue(3)：144-147,4.
透皮促进剂对散结止痛巴布膏中次乌头碱透皮的影响
Effects of penetration enhancers on percutaneous permeation of hypaconitine in Sanjiezhitong cataplasm
摘要
Abstract
AIM To investigate the effect of penetration enhancers on percutaneous absorption of hypaconitine in Sanjiezhitong eataplasm. METHODS Hypaconitine in skin exudate was determined by HPLC. Rat abdominal skin and Franz cells were used in the in-vitro diffusion test to examine the different concentrations of azone and eucalyptus oil on the permeation rates of hypaconitine in Sanjiezhitong cataplasm. RESULTS The permeability of hypacontine in Sanjiezhitong cataplasm was 0.65 ng· cm-2· h-1. The flux of hypacotine across rat abodominal skin was enhanced up to 9.87 times and 12.23 times compared with control group in the presence of 2％ azone + 10％ PG and 2％ eucalyptus oil. CONCLUSION 2％ eucalyptus oil or 2％ azone and 10％ PG composite agent could be selected as penetration enhancers for hypaconitine in Sanjiezhitong cataplasm.关键词
巴布膏/次乌头碱/透皮吸收/透皮促进剂Key words
cataplasm/ hypaconitine/ permeability/ penetration enhancer引用本文复制引用
马玲玲,努尔拉江·帕合尔丁,王丽梅,弓艺涓,李伟,沈腾,王建新..透皮促进剂对散结止痛巴布膏中次乌头碱透皮的影响[J].中国临床药学杂志,2011,20(3):144-147,4.基金项目
上海市科学技术委员会中药现代化专项资助(编号07DZ19713) （编号07DZ19713）
国家重大科技专项经费资助(编号2009ZX09310-006) （编号2009ZX09310-006）
