中国临床药学杂志2011，Vol.20Issue(3)：151-154,4.
山豆根多糖硫酸化修饰及其体外抗HBV活性测定
Sulfated modification for sophora subprostrate polysaccharide and anti-HBV activity determination of the modifiers
张玉 1蒋小丰 1张名洋 1罗瑜 1李琴韵1
作者信息
- 1. 上海中医药大学中药学院化学教研室,上海,201203
- 折叠
摘要
Abstract
AIM To modify sophora subprostrate polysaccharide(SSP) of the sulfated, and to determine anti-HBV activity. METHODS SSP was extract from sophora subprostrate , which was modified by chlorosulfonic acid-pyridine method. Products were identified by infrared spectrum(IR). The anti-HBV activity of modification production was tested by MTT method. RESULTS Analysis of IR spectrum for determination of SSP before and after modification showed that sulfate and polysaccharides have been combined into esters,and they had anti-HBV effect. CONCLUSION The experiments in vitro for determining anti-HBV activity show that modification production can enhance inhibitory action of HbeAg, HBsAg to 2 215 cells culture medium transfected by HBV.关键词
山豆根多糖/硫酸化修饰/氯磺酸-吡啶法/抗HBVKey words
sophora subprostrate polysaccharide/ sulfated modification/ chlorosulfonic acid-pyridine method/ anti-HBV引用本文复制引用
张玉,蒋小丰,张名洋,罗瑜,李琴韵..山豆根多糖硫酸化修饰及其体外抗HBV活性测定[J].中国临床药学杂志,2011,20(3):151-154,4.
