实用医学杂志2011，Vol.27Issue(12)：2257-2260,4.DOI:10.3969/j.issn.1006-5725.2011.12.066
甲状旁腺激素基因多态性对广东地区老年人骨密度的影响
Effects of gene polymorphisms of parathyroid hormone on bone mineral density in the elderly in Guangdong
摘要
Abstract
Objective To Investigate the correlation between the gene polymorphisms of parathyroid hormone (PTH) and bone mineral density (BMD) in the elderly in Guangdong district. Methods Five hundred and forty-nine subjects were randomly chosen from Guangdong district [aged 65 ～ 87 years , (71.03±7.37) years ].The genotypes of PTH were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RELP), and the BMD of lumhar, inter, trach, vertebrae, femur neck, and Ward's were measured by dualenergy X-ray absorptionmetry ( DEXA). Results The distribution of PTH genotypes were : BB 69.6％ (382 cases) ,Bb 27.0％ (148 cases),bb 3.4％(19 cases). The distribution of PTH genotypes was in accordance with HardyWeinberg equilibrium. There was no significant difference in BMD among cases with different PTH genotypes (P ＞0.05). Conclusion There is no relationship between gene polymorphisms of PTH and BMD in the elderly in Guangdong district.关键词
Bone Mineral Density (BMD) / Parathyroid hormone (PTH) / Gene polymorphismsKey words
Bone Mineral Density (BMD) / Parathyroid hormone (PTH) / Gene polymorphisms引用本文复制引用
何斌,蒋文玲,王瑞雪,董婷,李东风,吴文,黄小穗,杨艳红,林凯,邓海鸥,智喜梅,蔡雪珍..甲状旁腺激素基因多态性对广东地区老年人骨密度的影响[J].实用医学杂志,2011,27(12):2257-2260,4.基金项目
广东省重点攻关项目(编号:2001C30706 （）
2002B31101 （）
2005B3237 （）
2007B031503003) （）
广东省医学科研基金(编号:A2006004) （编号:A2006004）
广东省自然科学基金(编号:8151008008000002,8151008008000003) （编号:8151008008000002,8151008008000003）
