中国病理生理杂志2011，Vol.27Issue(6)：1103-1108,6.DOI:10.3969/j.issn.1000-4718.2011.06.011
Th17细胞联合CD3+CD8-IL-21+T细胞升高与宫颈癌发生发展的关系
Elevation of blood Th17 cells and CD3+CD8-IL-21+ T cells in patients with cervical cancer
摘要
Abstract
AIM: To investigate the role of Th17 cells in the patients with cervical cancer.METHODS: We measured the peripheral levels of Th17 cells and CD3+ CD8- IL - 21+ T cells in 37 cervical cancer ( CC ) patients, 25 cervical intraepithelial neoplasia ( CIN ) patients and 18 healthy controls by flow cytometry.The percentages of Th17 cells and CD3+ CD8- IL-21+ T cells in total CD4+ cells were calculated.RESULTS: Compared with controls, the patients with CC or CIN had higher proportions of Th17 ceUs ( all P ＜ 0.01 ) and CD3+ CD8-IL-21+ T cells ( all P ＜ 0.05 ).Notably, in CC patients, the increased percentages of Th17 cells and CD3+ CD8- IL- 21+ T cells were independently associated with the clinical stage( all P ＜ 0.05 ), lymph node metastasis (P＜0.01,P＜0.05) and vasoinvasion ( all P ＜ 0.01 ), while the elevated percentage of CD3+ CD8- IL-21+ T cells was also associated with the tumor size( P ＜ 0.01 ).Furthermore, the percentage of Th17 cells was positively correlated with that of CD3+ CD8- IL-21+ T cells in healthy controls and CC patients, but not in CIN patients.CONCLUSION: Our results indicates a possible role of Th17 cells in CC patients correlated with CD3+ CD8- IL-21+ T cells, and the elevated percentage of circulating Th17 cells may be involved in the development and progression of cervical cancer.关键词
宫颈肿瘤/宫颈上皮内瘤变/Th17细胞/CD3+CD8-IL-21+/T细胞Key words
Cervical neoplasms/ Cervical intraepithelial neoplasia/ T helper 17 cells/ CD3+CD8-IL-21+ T cells分类
医药卫生引用本文复制引用
张妍,崔保霞,马道新,刘艺,田永菊,侯菲,张文静..Th17细胞联合CD3+CD8-IL-21+T细胞升高与宫颈癌发生发展的关系[J].中国病理生理杂志,2011,27(6):1103-1108,6.基金项目
山东省优秀中青年科学家科研奖励基金资助项目(No.2006BS03060) （No.2006BS03060）
教育部留学回国人员科研启动基金资助项目(No.26010105450904) （No.26010105450904）
