首页|期刊导航|中华医学杂志（英文版）|Treatment of depression using sleep electroencephalogram modulated repetitive transcranial magnetic stimulation
中华医学杂志（英文版）2011，Vol.124Issue(12)：1779-1783,5.DOI:10.3760/cma.j.issn.0366-6999.2011.12.004
Treatment of depression using sleep electroencephalogram modulated repetitive transcranial magnetic stimulation
Treatment of depression using sleep electroencephalogram modulated repetitive transcranial magnetic stimulation
摘要
Abstract
Background As a treatment of depression, the efficacy of conventional repetitive transcranial magnetic stimulation (rTMS) is limited, and symptoms recurrence is easy to occur after the treatment. This study aimed to examine the efficacy and safety of sleep electroencephalogram modulated repetitive rTMS (SEM-rTMS) in the treatment of depression.Methods After 7 days without psychoactive medication, 164 patients with clinically defined depression were randomly divided into 3 groups: SEM-rTMS group (n=57), conventional rTMS (C-rTMS, n=55) group and sham-rTMS group (n=S2). Every patient was treated with the corresponding method for 30 minutes everyday for 10 days. Before and after scores on the 24-item Hamilton rating scale for depression (HAMD-24) and the clinical outcome on the 10th day of therapy for all subjects were analyzed.Results Twenty-two cases in the SEM-rTMS group obtained improved mood as compared to 6 in the C-rTMS group and 2 in the sham-rTMS group (X2=15.89, P=0.0004). After completion of the rTMS phase of the protocol, a (51±5)% reduction of HAMD-24 scores from the baseline in the SEM-rTMS group was found compared with a (34±4)% in the C-rTMS group (g=26.09, P=0.001) and a (14±3)% in sham-rTMS group (q=57.53, P=0.000). The 88% total effective rate in the SEM-rTMS group was significantly higher than 68% in the C-rTMS group and 20% in the sham-rTMS group (X2=12.01, P=0.0025). No significant side effects were noted.Conclusion SEM-rTMS is an effective and safe way for treating depression with repetitive transcranial magnetic stimulation (ChiCTR-TRC-00000438).关键词
depressive disorder/transcranial magnetic stimulation/clinical outcomeKey words
depressive disorder/transcranial magnetic stimulation/clinical outcome引用本文复制引用
HE Ming-li,GU Zheng-tian,WANG Xin-yi ,SHI Heng-ping..Treatment of depression using sleep electroencephalogram modulated repetitive transcranial magnetic stimulation[J].中华医学杂志（英文版）,2011,124(12):1779-1783,5.基金项目
This study was supported by grants from the Social Development Guide Projects of Science and Technology Office,Jiangsu Province (No.BS2005629) and "The Six Major Expert Peaks" Projects of Jiangsu Provincial Government (No.Surentong (2006) 174) （No.BS2005629）
