中国普通外科杂志2011，Vol.20Issue(5)：439-442,4.
手术联合131碘治疗分化型甲状腺癌效果观察
Effect of surgical treatment combined with 131-iodine therapy on differentiated thyroid carcinoma
摘要
Abstract
Objective To observe the clinical effect of surgical treatment combined with 131I therapy on differentiated thyroid carcinoma ( DTC ). Methods One hundred and forty-two patients with DTC undergoing subtotal or total thyroidectomy along with selective neck dissection from January 2000 to December 2004 in our hospital were included. After operation 90 cases given 131I ablative therapy combined with replacement therapy of thyroxine tablets were assisned as group A, and 52 cases given thyroxine tablets alone without 131I therapy were assigned as group B. Results In group A, the thyroid remnants of patients were all fully ablated after 1 - 4 courses of 131I treatment and the success rate of first course was 71. 1％; the total response rate of metastasis therapy was 91. 1％ , in which the response rates were 95. 1％ , 88.9％ and 72.7％ for lymph nodes metastasis, lung metastasis and bone metastasis, respectively. The incidence of adverse reactions was significantly different between the patients with total thyroidectomy ( 42.0 ％ ) and with subtotal thyroidectomy ( 77.5 ％ ) ( P ＜ 0. 01 ). The recurrence and survival rate for 10 years following surgery was 6.7％ and 94. 4％ in group A and 19. 2％ and 80. 8％ in group B, and both were significantly different beween the two groups ( both P ＜ 0. 05 ). Conclusions Surgical treatment combined with 131I treatment and thyroid hormone replacement therapy have good efficacy for thyroid ablation and metastasis therapy, which effectively reduces recurrence and metastasis rate of DTC after surgery and also shows good long-term effects.关键词
甲状腺肿瘤/外科学/癌,分化型/131碘/治疗应用Key words
Thyroid Neoplasms/ surg/ Carcinoma, Differentiated/ 131 I/ther use分类
医药卫生引用本文复制引用
谭介恒,凌文龙,蓝秋丽..手术联合131碘治疗分化型甲状腺癌效果观察[J].中国普通外科杂志,2011,20(5):439-442,4.基金项目
广西医疗卫生重点科研课题资助项目(2000985) （2000985）
