癌变·畸变·突变2011，Vol.23Issue(3)：181-185,5.DOI:10.3969/j.issn.1004-616x.2011.03.005
维生素A和E抗辐射氧化损伤作用的研究
The effect of vitamin A and vitamin E against Co60 radiationinduced oxidative injury
王欣 1王璐 1陈宏莉 1柏桦 1王钊 1刘江正 1海春旭1
作者信息
- 1. 第四军医大学军事毒理学教研室,陕西,西安710032
- 折叠
摘要
Abstract
OBJECTIVE: To study the antagonistic effects of vitamin A and vitamin E against Co60 radiationinduced oxidative injury. METHOD: Experiment 1: Rats were divided into five groups, including control,radiation, radiation + vitamin A, radiation + vitamin E and radiation + half dose of vitamin A and vitamin E. Beforeexposure to radiation, rats were treated with intragastrically with 30 mg/kg vitamin A, 30 mg/kg vitamin E, or 15 mg/kgvitamin A + 15 mg/kg vitamin E. Experiment 2: Rats were divided into seven groups, including control,radiation, radiation + 30 mg/kg vitamin E, radiation + 30 mg/kg vitamin E + different concentrations of vitaminA, ranging from 2.5 mg/kg to 20 mg/kg. Before the exposure to radiation, rats received intragastrically 30 mg/kg vitaminE, or 30 mg/kg vitamin E + different concentration of vitamin A. At day 7, rats were exposed to 6 Gy Co60 radiation. Atday 10, the rats were sacrificed, and serum and tissues were collected for analysis. RESULTS: Vitamin A and vitaminE alone could protect the rats against the injury induced by radiation. When the concentration of vitamin E was fixed at 30mg/kg, different concentrations of vitamin A resulted in the increase of MDA, the decrease of SOD and CAT activities and the content of vitamin E, in a dose-dependent manner. CONCLUSION: Under certain concentration, vitamin A and vitamin E could produce antagonistic effect.关键词
维生素A/维生素E/辐射损伤/丙二醛/超氧化物歧化酶/过氧化氢酶Key words
vitamin A/ vitamin E/ radiation/ MDA/ SOD/ CAT分类
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王欣,王璐,陈宏莉,柏桦,王钊,刘江正,海春旭..维生素A和E抗辐射氧化损伤作用的研究[J].癌变·畸变·突变,2011,23(3):181-185,5.
