癌变·畸变·突变2011，Vol.23Issue(3)：216-218,3.DOI:10.3969/j.issn.1004-616x.2011.03.014
胡桃楸水提物的遗传毒性及抗诱变作用研究
Study on the genetoxic and anti-mutagenesis effects of juglans mandshurica maxim extract
摘要
Abstract
OBJECTIVE: To discuss the mutagenesis and anti-mutagenesis effects of juglans mandshurica maxim extract (JMME) and to evaluate whether juglans mandshurica is genotoxic or not. METHODS: To choose 80 KM mice, and randomly grouped negative control group, positive control group (CP, 0.04 g/kg), water extract groups with different dose JMME (6.55, 13.09, 26.18 g/kg, 1/8, 1/4, 1/2 LD50), and antimutagenicity groups with different dose JMME water extract and CP (0.04 g/kg). There were 8 groups with 10 mice each group. Test whether the JMME had genotoxicity and anti-mutagenic effect, marrow micronuclei test was carried out. RESULTS: The micronucleus incidence of negative control group was 2.65‰, and that of positive control group was 28.82 ‰ (P＜0.01). But there were little statistical differences (P＞0.05) between the water extract groups with different doses JMME and the negative control group. Comparing the antimutagenicity groups with the positive control group, the low dose (6.55 g/kg) group showed no statistical significance (P＞0.05), but both the intermediate dose (12.09 g/kg) group and the high dose (26.18 g/kg) group had significant difference (P＜0.05), and the high dose group was lower than the intermediate group (P＜0.05).CONCLUSION: Under our experimental conditions, JMME had no genotoxicity. For the micronucleus incidence induced by CP, it had some dose-dependent anti-mutagenesis effect.关键词
胡桃楸水提物/急性毒性/诱变/抗诱变Key words
juglans mandshurica maxim extract/ genetoxic/ mutagenesis/ anti-mutagenesis分类
医药卫生引用本文复制引用
田玉玲,李淑红,刘冰,刘利,崔黎明..胡桃楸水提物的遗传毒性及抗诱变作用研究[J].癌变·畸变·突变,2011,23(3):216-218,3.基金项目
吉林省卫生厅科研基金资助课题(20060978) （20060978）
