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胚胎期暴露氰戊菊酯对中年CD-1小鼠空间学习记忆能力的影响

李学伟 陈贵海 马汉 王飞 陶飞 何燕 徐德祥

安徽农业大学学报2011,Vol.38Issue(3):337-340,4.
安徽农业大学学报2011,Vol.38Issue(3):337-340,4.DOI:CNKI:34-1162/S.20110419.0924.017

胚胎期暴露氰戊菊酯对中年CD-1小鼠空间学习记忆能力的影响

Effects of embryo exposed to fenvalerate on spatial ability of learning and memory in the middle-aged CD-1 mice

李学伟 1陈贵海 1马汉 1王飞 1陶飞 1何燕 1徐德祥2

作者信息

  • 1. 安徽医科大学第一附属医院神经内科,合肥,230022
  • 2. 安徽医科大学卫生管理学院毒理系,合肥,230032
  • 折叠

摘要

Abstract

The effects of embryo exposed to fenvalerate on spatial ability of learning and memory in the middle-aged CD-1 mice were explored. Six-arm radial water maze (RAWM) was used to evaluate spatial ability of learning and memory in the 13-month-old CD-1 mice, including fenvalerate-exposure group in embryo and normal control group. The results showed that the latency and the number of errors in the fenvalerate group were significantly more than those in the control group (Ps<0.05) in both the learning and the memory phase of the RAWM. Therefore, the exposure to fenvalerate in embryo could accelerate age-related impairment of the spatial learning and memory in the CD-1 mice.

关键词

氰戊菊酯/衰老/学习/记忆

Key words

fenvalerate/ aging/ learning/memory

分类

农业科技

引用本文复制引用

李学伟,陈贵海,马汉,王飞,陶飞,何燕,徐德祥..胚胎期暴露氰戊菊酯对中年CD-1小鼠空间学习记忆能力的影响[J].安徽农业大学学报,2011,38(3):337-340,4.

基金项目

国家自然科学基金项目(30872730)资助. (30872730)

安徽农业大学学报

OA北大核心CSCDCSTPCD

1672-352X

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