首页|期刊导航|中华医学杂志（英文版）|Effect of probucol on vascular remodeling due to atherosclerosis in rabbits: an intravascular ultrasound study
中华医学杂志（英文版）2011，Vol.124Issue(12)：1840-1847,8.DOI:10.3760/cma.j.issn.0366-6999.2011.12.015
Effect of probucol on vascular remodeling due to atherosclerosis in rabbits: an intravascular ultrasound study
Effect of probucol on vascular remodeling due to atherosclerosis in rabbits: an intravascular ultrasound study
摘要
Abstract
Background Probucol is known to reduce the development of atherosclerotic lesions, but its impact on vascular remodeling associated with de novo atherosclerosis is incompletely understood. We therefore examined the effect of probucol on vascular remodeling in a rabbit model of established atherosclerosis.Methods Aortic atherosclerosis was induced by a combination of endothelial injury and 10 weeks' atherogenic diet. Animals were then randomized to receive the foregoing diet without or with 1% (wt/wt) probucol for 16 weeks. At the end of week 26, in vivo intravascular ultrasound, pathological, immunohistochemical and gene expression studies were performed.Results Probucol significantly decreased vessel cross-sectional area, plaque area and plaque burden without effect on lumen area. More negative remodeling and less positive remodeling occurred in the abdominal aortas of probucol group than the control group (56% vs. 21%, 18% vs. 54%, respectively, both P<0.01). In addition, the probucol group showed a smaller mean remodeling index relative to the control group (0.93 ± 0.13 vs. 1.05 ±0.16, P<0.01). Furthermore, probucol treatment decreased macrophage infiltration, inhibited apoptosis of cells within plaques, and reduced the production of matrix metalloproteinases-2, -9, cathepsin K and cathepsin S (all P<0.01).Conclusions These findings suggest that probucol may attenuate the enlargement of atherosclerotic vessel walls and be associated with a negative remodeling pattern without affecting the lumen size. This effect may involve inhibition of extracellular matrix degradation and prevention of apoptosis in atherosclerotic plaques.关键词
arteriosclerosis/intravascular ultrasonography/plaque/vascular remodeling/probucolKey words
arteriosclerosis/intravascular ultrasonography/plaque/vascular remodeling/probucol引用本文复制引用
LI Ting-ting,XIE Yi,GUO Yuan,TIAN Hong-bo,ZHANG Jian-ning,PENG Jie,ZHANG Yun..Effect of probucol on vascular remodeling due to atherosclerosis in rabbits: an intravascular ultrasound study[J].中华医学杂志（英文版）,2011,124(12):1840-1847,8.基金项目
This study was supported by a Key Project from Department of Science and Technology of Shandong Province,China (No.2007GG20002025). （No.2007GG20002025）
