常州大学学报（自然科学版）2011，Vol.23Issue(1)：15-18,4.
4,6-二氯-2-甲硫基嘧啶的合成
Research on the Synthesis of 4,6-Dichloro-2-Methylthiopyrimidine
方永勤 1郭丽婷1
作者信息
- 1. 常州大学,设计研究院,江苏,常州,213164
- 折叠
摘要
Abstract
Sodium 2-thiobarbiturate was synthesized from the reaction of thiourea and diethyl malonate, with 96.7％ yield.4, 6-Dihydroxy-2-methylthiopyrimidine was prepared by methylation of sodium 2 - thiobarbiturate, with 86.9％ yield.4, 6- Dichloro- 2- methylthiopyrimidine was achieved by chloration, with 91.5％ yield.The total yield was 76.9％.The content of the product was more than 99.0％.The structures of the intermediates and target product were identified by IR and 1H NMR.关键词
4,6-二氯-2-甲硫基嘧啶/氯化/缚酸剂/甲基化Key words
4, 6-dichloro-2-methylthiopyrimidine/ chloration/ acid-catcher/ methylation分类
化学化工引用本文复制引用
方永勤,郭丽婷..4,6-二氯-2-甲硫基嘧啶的合成[J].常州大学学报（自然科学版）,2011,23(1):15-18,4.
