中国病理生理杂志2011，Vol.27Issue(6)：1230-1233,1239,5.DOI:10.3969/j.issn.1000-4718.2011.06.035
NMDA受体在癫痫发病机制中的作用
NMDA receptor in the pathogenesis of epilepsy
摘要
Abstract
Epilepsy is a chronic recurrent transient brain dysfunction syndrome. Seizure is correlated with the enhancement of glutamate responses mediated by N - methyl - D - aspartate ( NMDA ) receptor. NMDA receptor - mediated signal transduction is critical for synaptic plasticity, learning and memory. When epilepsy occurs, the NMDA receptors are up -regulated and the corresponding ion channels are kept open so that the neurons discharge continuously. At the same time, increased intracellular calcium causes the disorder of calcium homeostasis, resulting in neuron death. Postsynaptic density protein- 95 ( PSD -95 ), localized to NMDA receptor, may be involved in the pathophysiological process of seizure. As a selective NMDA receptor antagonist, the NR2B subunit selective antagonist has broad clinical application prospects in acute and chronic seizures.关键词
受体,N-甲基-D-天冬氨酸/癫痫Key words
Receptors/N - methyl - D - aspartate/ Epilepsy分类
医药卫生引用本文复制引用
彭毓棻,宋治..NMDA受体在癫痫发病机制中的作用[J].中国病理生理杂志,2011,27(6):1230-1233,1239,5.基金项目
国家自然科学基金资助项目(No.30971534) （No.30971534）
