浙江医学2011，Vol.33Issue(7)：1010-1013,4.
氯吡格雷联用质子泵抑制剂对再次心血管不良事件影响的Meta分析
Clopidogrel plus proton pump inhibitors increases recurrent major adverse cardiac events: A Meta-Analysis
杨俊 1戴一扬 1张召才 2张彩伢3
作者信息
- 1. 310013,杭州,浙江医院消化科
- 2. 浙江大学医学院附属第二医院心脏中心
- 3. 浙江大学城市学院
- 折叠
摘要
Abstract
Objective To evaluate the effects of clopidogrel plus proton pump inhibitors (PPI) on recurrent major adverse cardiac events (MACE).Methods Databases including PubMed, MEDLINE, METAMED, CBM and Wanfang were searched.Meta- Analysis was conducted with RevMan 4.2 software to analyze published clinical studies on incidence of recurrent MACE and rehospitalization in patients taking clopidogrel, with and without concomitant PPL Results Eight studies covering 51191 patients were included, among which 18618 patients taking clopidogrel plus PPI, 32573 patients taking clopidogrel alone.Result showed thatthe incidence of MACE in clopidogrelplus PPI group was significantly higher than that of clopidogrel alone group (OR = 1.55, 95％CI: 1.47～1.64, P＜0.01).The stability of the results was confirmed by subsequent sensitivity analysis.Conclusion Patients taking clopidogrelplus PPI have higher risk of recurrent MACE and rehospitalization.关键词
氯吡格雷/质子泵抑制剂/心血管不良事件/Meta分析Key words
Clopidogrel / Proton-pump-inhibitors / Major adverse cardiac events / Meta-Analysis引用本文复制引用
杨俊,戴一扬,张召才,张彩伢..氯吡格雷联用质子泵抑制剂对再次心血管不良事件影响的Meta分析[J].浙江医学,2011,33(7):1010-1013,4.
