化工进展2011，Vol.30Issue(5)：1059-1064,1119,7.
相分离制备聚己内酯纳米纤维支架的工艺探讨
Fabrication of polycaprolactone nanofibrous scaffolds by thermally induced phase separation
摘要
Abstract
Polycaprolactone ( PCL ) three-dimensional ( 3D ) scaffold with spherulite and nanofibrous was first fabricated by thermally induced phase separation from a ternary PCL/dioxane/water system.The effects of aging temperature, ratio of dioxane and water on the morphology of nanofibrous scaffolds were investigated. The results showed that aging temperature played a crucial role in forming the unique nanofibrous structure. A higher gelation temperature or a higher content of water in the mixed solvent system was not favorable for the spherulite -like morphology of scaffold. Coalescence of nanofibers occurred, even spherulite -like structure disappeared at a gelation temperatures higher than 8℃ or lower than - 40℃ and at a proportion of water exceeding 12％.关键词
纳米纤维/相分离/球晶/聚己内酯/水Key words
nanofibrous/ phase separation/ spherulite/ polycaprolactone/ water分类
医药卫生引用本文复制引用
刘淑琼,肖秀峰,刘榕芳,钟章裕,焦简金..相分离制备聚己内酯纳米纤维支架的工艺探讨[J].化工进展,2011,30(5):1059-1064,1119,7.基金项目
国家自然科学基金(3060149 （）
30970887)及卫生部科学研究基金(WKJ 2008-02-037)项目. （WKJ 2008-02-037）
