中国普通外科杂志2011，Vol.20Issue(5)：485-490,6.
趋化因子受体5表达与乳腺癌临床病理特征及预后的相关性研究
Analysis of the correlation between CCR5 expression and clinicopathological features and prognosis of breast cancer
摘要
Abstract
Objective To study the expression and clinicopathological relevance of chemokine receptor 5 ( CCR5 ) in breast cancer tissues and metastatic axillary lymph nodes.Methods The paraffin specimens of 72 cases of invasive ductal carcinoma ( IDC ) along with the invoved axillary lymph nodes, 50 cases of breast fibroadenoma and 40 cases of normal mammary gland were collectod.The expression of CCR5 protein in those specimens was detected by immunohistochemical staining.Meanwhile, the expressions of C-erbB-2, P53,Ki-67, ER and PR in the specimens of IDC were also measured with immunohistochemical method.Finally,the immmohistochemical results were statistically analyzed with regard to correlations with their clinicopathological data.Results ( 1 ) The positive expression of CCR5 in IDC was 84.72％ (61/72 ) , breast fibroadenoma tissue presented low positive expression of CCR5 ( 14％ , 7/50 ) , and no CCR5 expression was found in normal breast tissue.(2) The expression of CCR5 in IDC had a positive correlation with lymph node metastasis ( x2 = 4.982, P = 0.026, r = 0.305 ).( 3 ) Of the 50 cases with axillary lymph node metastasis, CCR5 was simultaneously expressed both in primary cancer and its invoved axillary lymph nodes in 39 cases, which showed a high homology.(4) There was a low positive correlation between CCR5 and breast cancer oncogene C-erbB-2 ( P ＜ 0.05 , r = 0.291 ).( 5 ) CCR5 showed no relationship with age of onset, maximum diameter of tumor, mensis status or clinical stage ( P ＞ 0.05 ).( 6 ) CCR5 had no direct correlation with the expression of p53, Ki-67, ER, PR ( P ＞ 0.05 ).Conclusions CCR5 plays an important role in occurrence and development as well as axillary lymph node metastasis of breast cancer.CCR5 may be one of the indirect indicators to predict axillary lymph node metastasis and prognosis of breast cancer.关键词
乳腺肿瘤/病理学/趋化因子受体/C-erbB-2/p53/Ki-67/雌激体受体/孕激素受体/免疫组织化学Key words
Breast Neoplasms/pathol/ CCR5/ p53/ Ki-67/ C-erbB-2/ ER/ PR/ Immunohistochemistry分类
医药卫生引用本文复制引用
章阳,孟凡云,李文磊,范海燕,关众,周长鑫..趋化因子受体5表达与乳腺癌临床病理特征及预后的相关性研究[J].中国普通外科杂志,2011,20(5):485-490,6.基金项目
山东省自然科学基金资助项目(Y2007C090). （Y2007C090）
