摘要
Abstract
Objective To study the therapeutic effect of phenobarbital on infantile hepatitis syndrome ( IHS ). Methods Ninety infants with IHS were randomly divided into control group and treatment group. Infants in control group were treated with general drugs, while phenobarbital ( 5mg/kg, po tid ) was supplemented to infants in treatment group based on general drugs. The contents of serum alanine aminotransferase ( ALT ), aspartate aminotransferase ( AST ), gamma glutamyl transpeptidase ( GGT ), alkaline phosphatase ( ALP ), total bilirubin ( TBIL ), direct bilirubin ( DBIL ) and indirect bilirubin ( IBIL ) were determined for all infants. Results Total effective rate of treatment group was significantly higher than that of control group (x2= 5. 075, P ＜ 0.05 ), and the average treatment duration of treatment group was significantly shorter than that of control group. There were significant differences in the contents of ALT, AST, TBIL, DBIL and IBIL before and after treatment in control group ( t was 20.85, 25. 13, 25. 11, 27.86 and 23. 17 respectively, P ＜ 0.05 ). And in treatment group the contents of ALT, AST, TBIL, DBIL and IBIL before treatment were significantly different from those after treatment ( t was 23.23, 25.49, 27.22, 33.07 and 27.72 respectively, P ＜ 0.05 ). After treatment there were significant differences in the contents of serum TBIL, DBIL and IBIL between treatment group and control group ( t was 7.81, 6.71 and 5.35 respectively, P ＜0.05 ), but there was not any statistical difference in GGT and ALP between two groups before and after treatment ( P ＞ 0.05 ). Conclusion Phenobarbital is very effective in supplementary treatment of IHS and is worth popularizing.关键词
肝炎综合征/苯巴比妥/婴儿/胆红素/转氨酶Key words
hepatitis syndrome/ phenobarbital/ infant/ bilirubin/ aminotransferase分类
医药卫生
