山东医药2011，Vol.51Issue(17)：7-9,3.
老年早期糖尿病肾病患者血清炎症因子、外周血NF-κB活性变化及阿托伐他汀的治疗作用
Changes of serum proinflammatory factors and peripheral blood NF-κB activity in elderly diabetics with early nephropathy and treatment effect of Atorvastatin
摘要
Abstract
Objective To observe the changes of serum proinflammatory factors and peripheral blood NF-κB activity in elderly diabetics with early nephropathy, and study the treatment effect of Atorvastatin.Methods Ninety-six patients with T2DM, according to whether the merger DN divided into DM group( n = 30), DN group( n =66).DN group randomly divided into DM conventional treatment group(DN1 group, n=31), DM conventional therapy + Atorvastatin treatment group(DN2 group, n =35), and choosing 30 cases of healthy check-up persons as control group (NC group).Observing serum proinflammatory factors respectively with hypersensitive C-reactive protein(hs-CRP), TNF-α, IL-6, IL-1β and peripheral blood NF-κB p65 of phosphorylation level.Results In NC group, DM group, DN group, serum proinflammatory factors hs-CRP,TNF-α, IL-6, IL-1β level and peripheral blood NF-κB p65 activity were increasing gradually (P＜0.01 or ＜0.05).After treatment of Atorvastation, NF-κB p65 activity and proinflammatory factors hs-CRP, TNF-α, IL-6, IL-1β dcscended obviously(P ＜0.01 or ＜0.05).Conclusions Atorvastatin inhibits peripheral blood NF-κB p65 activity in elderly early DN patients, and could reduce serum proinflammatory factors hs-CRP, TNF-α, IL-6, IL-1β levels, and improve irflammatory condition.关键词
糖尿病,2型/糖尿病肾病/NF-κB/炎症趋化因子类/阿托伐他汀Key words
diabetes mellitus/ type 2/ diabetic nephropathies/ NF-kappa B/ chemokines/ Atorvastatin分类
医药卫生引用本文复制引用
李建英,路文盛,颜晓东,郭进,刘斐,陈健,叶伟林..老年早期糖尿病肾病患者血清炎症因子、外周血NF-κB活性变化及阿托伐他汀的治疗作用[J].山东医药,2011,51(17):7-9,3.基金项目
广西科技厅青年科学基金课题(0991062). （0991062）
