首页|期刊导航|中华医学杂志（英文版）|Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system
中华医学杂志（英文版）2011，Vol.124Issue(12)：1901-1905,5.DOI:10.3760/cma.j.issn.0366-6999.2011.12.024
Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system
Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system
摘要
Abstract
Objective Sulfur dioxide was considered to be toxic and detrimental to human health. However, this review highlights recent advances that suggest sulfur dioxide might be a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions.Data sources The data used in this review were mainly from the studies reported in Medline and PubMed published from 1986 to 2010.Study selection Original articles and critical reviews selected were relevant to exogenous and endogenous sulfur dioxide.Results The sulfur dioxide/aspartate amino transferase pathway is endogenously generated in the cardiovascular system, and sulfur dioxide shows broad bioactive effects, such as antihypertension, vasodilation, and amelioration of vascular remodeling. A disturbed sulfur dioxide/aspartate amino transferase pathway is known to be involved in the pathogenesis of many cardiovascular diseases, such as ischemia-reperfusion injury, monocrotaline-induced pulmonary hypertension, athrosclerosis, spontaneous hypertension and hypoxic pulmonary hypertension. Furthermore, in experimental studies the prognosis of these cardiovascular diseases can be improved by targeting endogenous sulfur dioxide.Conclusion The findings suggest that sulfur dioxide is a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions.关键词
cardiovascular diseases/endogenous/exogenous/sulfur dioxideKey words
cardiovascular diseases/endogenous/exogenous/sulfur dioxide引用本文复制引用
CHEN Shan-shan,TANG Chao-shu,JIN Hong-fang,DU Jun-bao..Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system[J].中华医学杂志（英文版）,2011,124(12):1901-1905,5.基金项目
This work was supported by the grants from the National Natural Science Foundation of China (No.81070111,No.30821001 and No.30801251),the Major State Basic Research Development Program (No.2011CB503904) and the Natural Science Foundation of Beijing (No.7112130). （No.81070111,No.30821001 and No.30801251）
