针灸临床杂志2011，Vol.27Issue(5)：51-54,4.
电针治疗抑郁模型大鼠快速起效海马区BDNF-TrkB机制研究术
Rapid-effect Mechanism on BDNF-TrkB in Hippocampus of Depressive Model Rats by Electro-acupuncture
摘要
Abstract
Objective:To explore the rapid antidepressant action and the protection mechanism of neurons in hippocampus by electro- acupuncture(EA). Methods:32 SD rats were randomly divided into control,model,medication and EA group, 8 in each group. Depressive model rats were replicated by chronic unpredicatable mild stress induction, and immunohistochemistry was used to observe the expression of BDNF and TrkB positive neurons at CA1 ,CA3 and DG of hippocampus in each group after 7 days treatment. Results:①In model group,the expression of BDNF and TrkB positive neurons in hippocampus decreased. It was embodied as the average gray value increased while the total objective area decreased. ②After 7 days treatment,the average gray value of BDNF and TrkB positive neurons decreased in EA group, compared with meditation group, especially at CA3 of hippocampus( P ＜0. 01 ). ③After 7 days treatment,the total objective area of BDNF and TrkB positive neurons increased significantly in EA group, compared with meditation group, especially at DG of hippocampus (P ＜0. 05 ). Conclusion:EA can maintain neuronal survival and stimulate neurogenesis in hippocampus; Antidepressant rapid - effect mechanism by EA may re]ate to the rapidly increased expression of BDNF and TrkB.关键词
抑郁症/电针/BDNF/TrkBKey words
Depression/ Electro - acupuncture/ BDNF/ TrkB分类
医药卫生引用本文复制引用
卢金花,姜劲峰,王玲玲,陈丽智..电针治疗抑郁模型大鼠快速起效海马区BDNF-TrkB机制研究术[J].针灸临床杂志,2011,27(5):51-54,4.基金项目
江苏省教育厅重点实验室开放课题,编号:KJA200803. （）
