实用肝脏病杂志2011，Vol.14Issue(4)：253-256,4.DOI:10.3969/j.issn.1672-5069.2011.04.005
肝复康对HSC-T6细胞Wnt信号转导通路调节作用的观察
The effects of Gangfukang compound on Wnt signaling pathway in hepatic stellate cell line
摘要
Abstract
Objective To study the effect of Ganfukang compound,a Chinese traditional herb medicine,on the expression of some regulatory factors of Wnt signaling pathway in hepatic stellate (HSC) -T6 cells. Methods HSC-T6 was dealt with middle concentration of Ganfukang compound. The expression changes of Wnt1 , Gsk-3β,β-catenin,cyclinD1 and α-SMA were analysed by RT-PCR and Western-blot. Results Except Gsk-3β,the expression of Wnt1, β-catenin,cyclinD1 and α-SMA were downregulated after treated with Ganfukang compound. Conclusion The anti-fihrosis roles of Ganf'ukang compound are related to several key regulatory factors in Wnt/β-catenin pathway,which might inhibit the transcription of α-SMA and decrease the production of extracellular matrix.关键词
肝纤维化/肝星状细胞/肝复康/Wnt/β-catenin通路Key words
Liver fibrosis/ Hepatic stellate cell/ Chinese herb medicine/Wnt/β-catenin pathway引用本文复制引用
张彩华,姜妙娜,袁丽君,李寒姝,赵赫男,李骢,贾玉杰..肝复康对HSC-T6细胞Wnt信号转导通路调节作用的观察[J].实用肝脏病杂志,2011,14(4):253-256,4.基金项目
辽宁省教育厅高等学校科研项目(编号:2009A190) （编号:2009A190）
