实用肝脏病杂志2011，Vol.14Issue(4)：257-258,261,3.DOI:10.3969/j.issn.1672-5069.2011.04.006
血清胆碱酯酶活性对慢性乙型肝炎肝组织病理分级分期的预测价值
Serum cholinesterase activity for predicting hepatic pathological gradings and stagings in patients with chronic hepatitis B
摘要
Abstract
Objective To predict the hepatic pathological gradings and stagings by serum cholinesterase (Che)activity in patients with chronic hepatitis B. Methods 419 consecutive patients with chronic hepatitis B were enrolled in the present study,and their hepatic pathological diagnosis were made and serum Che activity were determined. Results There were significant differences of serum Che activity between G1 and G2,G2 and G3,G3 and G4 (P=0.000,0.000,0.014);There were significant differences of serum Che activity between S2 and S3,and S3 and S4 (P=0.000,0.000) ; The accurate rates by Che were 55.65％ for G1,28.25％ for G2,27.83％ for G3, and 66.67％ for G4; and 43.33％ for SO, 6.49％ for S1, 19.01％ for S2, 31.11％ for S3, and 71.29％ for S4; The areas under ROC curve of serum Che activity for diagnosing G4 and S4 were 0.868 and 0.831 (P=0.000 and 0.000) ;The optimal cutoff value of' serum Che activity for prodicting G4 and S4 were no more than 5.235×103u/L and 5.535×103u/L,respectively,and the sensitivity,specificity,and accuracy were 1.000 and 0.822,0.678 and 0.758, and 0.687 and 0.771,respectively. Concluson Serum Che activity is an index for prodicting G4 and S4 in patients with chronic hepatitis B.关键词
乙型肝炎/胆碱酯酶/病理学/无创诊断Key words
Hepatitis B/ Cholinesterase/ Pathology/ Non-invasive diagnosis引用本文复制引用
张占卿,陆伟,饶敏,王雁冰,陈淑琴,童海涛,周毅..血清胆碱酯酶活性对慢性乙型肝炎肝组织病理分级分期的预测价值[J].实用肝脏病杂志,2011,14(4):257-258,261,3.基金项目
上海市科委科技计划项目(09411965800) （09411965800）
