江苏大学学报（医学版）2011，Vol.21Issue(4)：326-328,封3,4.
丁咯地尔预处理对坐骨神经损伤大鼠背根神经元细胞色素C表达的影响
Expression of cytochrome C in dorsal root ganglion neurons in rats of sciatic nerve lesion model and the effect of pretreatment with buflomedil
摘要
Abstract
Objective: To study the effects of buflomedil on the changes of cytochrome C expression in dorsal root ganglion neurons in rats of sciatic nerve lesion model. Methods: Forty- two SD rats were randomly divided into 3 group( n= 14) , the normal group, the model group and the buflomedil group, the later groupswere received saline and buflomedil 40 mg· kg-1 · d-1 respectively for14 d, then the sciatic nerve lesion models were performed. The expression of cytochrane C were detected by immunohistochemical method6 h, 12 h, 24 h, 48 h, 3 d, 4 d, and7 d after the operation, respectively. Results: There was less the cytochrome C expression in normal group. After12 h of themodel operation, the cytochrome C expression in model group increased obviously( P ＜ 0. 01 ) . The expressions of cytochrome C ni buflanedil group also decreased ( P ＜ 0. 01) 12 h after the sciatic nerve lesion, but less than those of model group ( P ＜0. 05 or0. 01). C onclusion : There are a number of the cytochrome C positive cells in normal group in dorsal root ganglion after sciatic nerve lesion, buflomedil can down- regulate the expression of cytochrome C to perform the neuro-protective effect by inh ibiting apoptois.关键词
丁咯地尔/坐骨神经/神经节/细胞色素CKey words
buflomedil/ sciatic nerve/ ganglia/ cytochrome C分类
医药卫生引用本文复制引用
林伟,苏建华,陈玉芳,张俊华,唐金荣,肖杭,薛建琴,耿瑜睿..丁咯地尔预处理对坐骨神经损伤大鼠背根神经元细胞色素C表达的影响[J].江苏大学学报（医学版）,2011,21(4):326-328,封3,4.基金项目
常州市科技局指导性科研项目(CS2008928) （CS2008928）
金坛市科技基金资助项目(TS2007069) （TS2007069）
金坛市133工程资助项目 （）
