江苏大学学报（医学版）2011，Vol.21Issue(4)：344-348,封3,6.
miRNAlet7、C-myc在非小细胞肺癌中的表达及意义
Expression and clinical pathological significance of miRNAlet7、C-myc in non-small cell lung cancer
摘要
Abstract
Objective: To study the effects of microRNA let7 、 C-myc on carcinogenesis and progression in non- small cell lung cancer( NSCLC) . Methods: In- situ hybridization was applied to detect the expression of let7 in68 cases of non- small cell lung cancer and 20 cases of adjacent lung tissues , while SP immunohistochemistry was adopted tomeasure C-myc in these specimens. Results: The positive rate of let7 in NSCLC group was 39. 7％ , which was lower than 75. 0％ in control group( X2 =6. 367 ,P ＜0. 05 ) , while the positive rate of C-myc in NSCLC gruup was 54. 4％ , which was higher than 25. 0％ in control group ( x2 = 4. 245 ,P ＜0. 05) . The positive rate of let7 and C-myc had no relation with clinic-pathological parameter ( P ＞0. 05 ) ; there was an obvious negative correlation between let7 and C-myc( r= - 0. 404 , P ＜ 0. 01 ) .The 2-year survival rate of positive let7 is higher than that of the negative group( X2 =4. 84 ,P = 0. 027 8) .There had no statistical significance between positive and negative groups of C-myc for two-year survival ( X2 =2. 47 ,P =0. 116 4). Conclusion : The lower expression level of let7 and high expression level of Cmyc were related with NSCLC, and further research were needed.关键词
非小细胞肺癌/miRNAlet7/C-myc/原位杂交/免疫组织化学Key words
non-small cell lung cancer/ microRNAlet7 / C-myc/ in- situ hybridization/ immunohistochemistry分类
医药卫生引用本文复制引用
胥传海,兰建云,严晓鸥,沈承红,严晓梅,冯一中..miRNAlet7、C-myc在非小细胞肺癌中的表达及意义[J].江苏大学学报（医学版）,2011,21(4):344-348,封3,6.基金项目
盐城市科技社会发展计划基金资助项目(YK2009103) （YK2009103）
