重庆医学2011，Vol.40Issue(20)：1988-1990,1994,4.DOI:10.3969/j.issn.1671-8348.2011.20.005
Survivin、Bax蛋白在喉病变组织中的表达及临床意义
Expression of Survivin and Bax protein in differ laryngeal disease and its clinical significance
蔡雯 1崔颖 2张婷婷 1张本2
作者信息
- 1. 辽宁医学院耳鼻咽喉-头颈外科专业研究生班,辽宁锦州,121001
- 2. 辽宁医学院附属第一医院耳鼻咽喉-头颈外科,辽宁锦州,121001
- 折叠
摘要
Abstract
Objective To examine the expression of apoptosis inhibitive protein( survivin) and pro-apoptosis protein( bax) in polyp vocal cord and displasia and glottic carcinoma , and investigate the relationship between the expression level of them and the clinical significance.Methods Immunohistochemical SP method was used to determine the expressions of Bax and Survivin proteins in polyp vocal cord and displasia and glottic carcinoma of 72 cases.Results Survivin protein was expressed in 24 samples of glottic carcinoma(70.83％) , which remark higher than the polyp vocal cord ( 25.00％ ) and displasia(58.33％).There were no differences of gender,age of glottic carcinoma between negative and positive of survivin protein groups(P＞0.05) , but we found that there were different effect of clinical stage between the two groups(P=0.0111).Bax protein was expressed in 24 samples of polyp vocal cord ( 87.5％ ) , which remark higher than the glottic carcinoma( 41.67％ ) and displasia( 54.17％ ).There were no differences of gender,age of glottic carcinoma between negative and positive of bax protein groups (P ＞ 0.05); but we found that there were different effect of clinical stage between the two groups(P=0.0183).Conclusion The both of survivin and bax were involve in regulation of the apoptosis and cell cycle of carcinoma of the larynx,which indicate that it may play a crucial role in the genesis and progression of laryngeal neoplasms.关键词
bcl-2相关X蛋白/声带息肉/喉不典型增生/声门区喉肿瘤/SurvivinKey words
bcl-2 associated X protein/ polyp vocal cord / displasia / glottic carcinoma / Survivin引用本文复制引用
蔡雯,崔颖,张婷婷,张本..Survivin、Bax蛋白在喉病变组织中的表达及临床意义[J].重庆医学,2011,40(20):1988-1990,1994,4.
