广东医学2011，Vol.32Issue(13)：1678-1681,4.
帕金森病患者血清中犬尿氨酸、犬尿喹啉酸及色氨酸的测定及临床意义
Significance of kynurenine, kynurenic acid and trptophane in patients with Parkinson's disease
摘要
Abstract
Objective To evaluate the serum kynurenine ( KYN ), kynuremc acid ( KYNA ) and trptophane ( TRP ) in Parkinson's disease ( PD ) patients and healthy controls. Methods The serum KYN. KYNA and TRP levels in 16 first episode PD patients, 36 PD patients treated by Madopar and 20 age - matched healthy controls were measured by high performance liquid chromatography - fluorescence ( HPLC - FLD ). KYNA/KYN and KYN/TRP ratios were calculated. Results The serum KYNA level and KYNA/KYN in PD patients treated by Madopar were significantly higher than those in first episode PD patients and controls ( P ＜ 0. 01 ). The serum TRP levels in first episode or Madopar treated PD patients was significantly higher than that in controls ( P ＜ 0. 01 ). Conclusion The serum KYN. KYNA and TRP levels in PD patients may be used for the diagnosis and treatment of PD.关键词
帕金森病/犬尿氨酸/犬尿喹啉酸/色氨酸/高效液相色谱Key words
Parkinson's disease/ kynurenine/ kynurenic acid/ tryptophane/ high performance liquid chromatography引用本文复制引用
唐亚梅,张付峰,刘勇,常丹丹,任亚萍..帕金森病患者血清中犬尿氨酸、犬尿喹啉酸及色氨酸的测定及临床意义[J].广东医学,2011,32(13):1678-1681,4.基金项目
国家自然科学基金资助项目(编号:30700260) （编号:30700260）
