中国药理学通报2011，Vol.27Issue(8)：1095-1097,3.DOI:10.3969/j.issn.1001-1978.2011.08.015
咪达唑仑对人定量药物脑电图δ频段功率百分比的影响
Effects of midazolam on the percentage of δ band power of quantitative pharmaco-EEG
摘要
Abstract
Aim To investigate the effects of midazolam on the percentage of δ band power of quantitative pharmco-EEG( QPEEG ). Methods 20 healthy male adults were randomly divided into 2 groups ( n= 10 each ) and were given iv injections of 0.05 mg · kg-1 and 0. 1 mg · kg-1 of midazolam respectively. The EEG samples were obtained before and at regular intervals following the midazolam injections. Power spectral analysis was conducted to check the EEG variations before and after the midazolam iv injections. Results After midazolam injections, the percentage of δ band power of QPEEG all increased in group Ⅱ( P ＜0.01 ),reached its peak after about 5 min, and then returned to normal after about 10 min. The percentage of δ bandpower of QPEEG had a trend of increase in group Ⅰ ,but was not statistically significant ( P ＞ 0.05 ). Conclusions Midazolam increases the percentage of QPEEG power at δ band in a dose-dependent manner,which suggests that the percentage of QPEEG power at δ band serves as an effective index of anesthesia depth monitering.关键词
咪达唑仑/定量药物脑电图/麻醉深度/监测/δ频段/功率百分比Key words
midazolam/ QPEEG/ anesthesia depth/ monitoring/δ band/ the percentage of power分类
医药卫生引用本文复制引用
王立伟,戴体俊,王建华,张党生,周美艳..咪达唑仑对人定量药物脑电图δ频段功率百分比的影响[J].中国药理学通报,2011,27(8):1095-1097,3.基金项目
国家自然科学基金资助项目(No 30872432,30471657,39970715) （No 30872432,30471657,39970715）
江苏省自然科学基金资助项目(No BK2001143) （No BK2001143）
徐州科技局资助项目(No xzzd1015) （No xzzd1015）
