中国药理学通报2011，Vol.27Issue(8)：1037-1041,5.DOI:10.3969/j.issn.1001-1978.2011.08.001
PI3K/Akt信号通路与肝纤维化
PI3K/Akt signaling pathway and liver fibrosis
摘要
Abstract
Phosphatidylinositol 3-kinase/Akt ( PI3 K/Akt ) signal pathway is an important intracellular signal transduction pathway.It plays important roles in inhibiting cell apoptosis and stimulating cell proliperation.PI3K/Akt signal transduction pathway is closely related to the occurrence and development of liver fibrosis.It is a promising way to study the pathogenesis and therapy of liver fibrosis through intervention of PI3K/Akt signaling pathway.This review briefly summarizes the PI3K/Akt pathway' s structure, intracellular signaling cascades and its role in liver fibrosis.关键词
磷脂酰肌醇3激酶/肝纤维化/肝星状细胞/增殖/凋亡/细胞因子Key words
phosphatidylinositol 3-kinase/ liver fibrosis/ hepatic stellate cell/ proliferation/ apoptosis/ cytokine分类
医药卫生引用本文复制引用
黄成,李俊,马陶陶..PI3K/Akt信号通路与肝纤维化[J].中国药理学通报,2011,27(8):1037-1041,5.基金项目
国家自然科学基金资助项目(No 30873081,81072686) （No 30873081,81072686）
